More than three dozen wild horse advocacy groups have voiced their desire for federal authorities to make greater use of the fertility control vaccine PZP to manage America’s wild horses.
The groups contend that the PZP vaccine is a cost-effective alternative to roundups and removals of wild horses from the range – a federal strategy which has been widely condemned as expensive and ineffective.
Today’s call for greater PZP use represents a major stand among groups advocating for better management of the mustangs that inhabit the vast western rangelands. They see it as a way to stave off the fiscal problems sparked by wild horse roundups, with an increasing share of the budget going toward the long-term care of the captive animals.
Neil Kornzse, the director of the Bureau of Land Management (BLM), the agency charged with managing America’s wild horses, admitted recently that the current system of roundups was failing. He said the agency’s policy of mustering and keeping the horses in facilities could potentially cost $US1 billion over the life-span of the horses.
Already, 70 percent of the BLM’s $US80 million Wild Horse and Burro Program budget was spent on roundups and removals, while less than 1 percent of that amount was spent on long available, humane and effective fertility control.
Groups supportive of the use of the PZP vaccine for humane wild horse management include the:
The BLM has removed more than 40,000 wild horses from public lands in the last seven years alone.
The National Academy of Sciences (NAS) recommended the use of PZP in its 2013 study, Using Science to Improve the BLM Wild Horse and Burro Program, saying it was “a more affordable option than continuing to remove horses to long-term holding facilities”.
The NAS study also noted that roundups and removals of wild horses were actually responsible for “facilitating high rates of population growth on the range”.
The NAS added that “removals are likely to keep the population at a size that maximizes population growth rates, which in turn maximizes the number of animals that must be removed through holding facilities”.
PZP is an immunocontraceptive vaccine. It works with a mare’s immune system to produce antibodies that block sperm receptor sites on the zona pellucida, a thin membrane surrounding the ovum.
Because it is non-hormonal, PZP does not:
PZP has been used for more than 25 years in the wild horses on the Assateague Island National Seashore in Maryland. In that time, the herd has been brought to more sustainable numbers and the overall health of horses as a result has improved substantially.
In 1990, few horses on Assateague lived past 15 years. Now, many are living 30 years or more.
And, because PZP is not permanent, the National Park Service managers can closely control the herd’s population, allowing for increased births as appropriate.
Management programs with PZP have also helped curtail and even end roundups in wild horse management areas in the West, such as the Pryor Mountains on the Montana/Wyoming border, McCullough Peaks in Wyoming and Spring Creek Basin and Little Book Cliffs in Colorado.
In Colorado’s Spring Creek Basin, no mustangs have been removed since 2011, thanks to a BLM-facilitated public-private partnership using the PZP vaccine.
In addition, the BLM has committed to bait trapping if, in the future, the removal of some mustangs was necessary to maintain range health. Bait trapping is a far less traumatic capture method than helicopter roundups.
A PZP project on the McCullough Peaks range in Wyoming, meanwhile, helped the wild horse population there achieve zero population growth within three years.
Increased use of PZP and a reduction in roundups and removals would also be a boon to US taxpayers, helping to curtail the cost of the existing program.
The public now spends about $US49,000 for each mustang that is removed from the range and not adopted. PZP, meanwhile, costs about $US27 per darted horse per year.
One economic model published in the Journal of Zoo and Wildlife Medicine showed that the BLM could save $US8 million over 12 years by using PZP in one herd management area alone. Multiply that by 179 HMAs and the cost-savings reach the hundreds of millions, according to the advocacy groups.
Largely unchecked by natural predators, many wild horse populations grow at rates of 18–25 percent per year. This unregulated growth can overtax vegetation and affect herd health as well as native wildlife populations. The Wild Free-Roaming Horses and Burros Act of 1971 requires the U.S. Bureau of Land Management (BLM) and USDA Forest Service to manage these free-roaming herds for a “thriving natural ecological balance.”
To ensure the sustainability and health of both horse herds and the public lands they roam, and to reduce the number of animals requiring either adoption or long-term care in holding areas, managers began to explore fertility control as an alternative management technique.
From 1978 into the 1980s, the BLM worked through a series of research contracts focusing primarily on development of a chemosterilant for wild stallions. In the early 1990s, research turned to silicone implants in mares in an effort to achieve fertility control. Although both routes produced fertility control, they had too many drawbacks and were eventually abandoned.
In light of these problems and the continuing need for some form of contraception, in 1991 researchers identified the desired characteristics for an ideal wild horse fertility control agent.
Specifically, the agent should:
How PZP works
In order for sperm to attach to the ovum and fertilize the egg, there must be complementary proteins on both the surface of the sperm and the zona pellucida (ZP) of the ovum. PZP acts as a foreign protein against which the treated mare produces antibodies (thus, the PZP fertility control agent is actually a vaccine). These antibodies attach to the mare’s zonae sperm receptors on the ovum and block fertilization. Domestic pig ovaries (obtained from slaughterhouses) are minced and the PZP is obtained from screening filtration. An adjuvant is mixed with the PZP to enhance its effectiveness when it is injected into mares intramuscularly. Once injected, it causes an immune response, making the mare infertile. Over time, the antibody titers fall and fertility returns. With the liquid vaccine, a booster injection can be given at 10 months to raise the titers back to the infertile range. This can be done each year for at least 4 years, after which time the effects may be more likely to become permanent. For this reason, current individual-level field trials involve only 1–4 years of treatment.
This list of needs would drive much of the U.S. research on wild horse contraception during the 1990s, including research funded by both the BLM and the U.S. Geological Survey (USGS). To meet the stated criteria, a National Park Service research team on Assateague Island National Seashore turned to an immunocontraceptive agent, porcine zona pellucida (PZP), which had been reported to block fertilization in dogs, rabbits, and primates. Experimental PZP application on the wild horses of Assateague Island commenced in 1988, resulting in promising reductions in the pregnancy rates of mares: by 1994, population growth began to stabilize solely through the use of PZP immunocontraception.
The Outlook for PZP
The PZP agent appears to meet most of the safety concerns of the BLM. The fact that PZP is a glycoprotein suggests that it should be digested before it can enter the food chain. Its effects passively wear off with time if annual injections are terminated; normal reproduction can be resumed following at least 4 years of use, and perhaps more. It does no harm if injected into mares that are already pregnant—they carry foals to term. Initial research suggests that PZP does not affect ovarian function or hormonal health. Life span seems to increase with improved health of treated mares, apparently due to the absence of stresses from pregnancy and lactation. Treated mares can live 5–10 years longer than untreated mares that continue to get pregnant and produce young. An initial study suggested that harem behaviors are not influenced, and more in-depth investigations are currently underway. There appear to be no generational effects; offspring of treated mares are able to reproduce normally. Finally, at least some forms of PZP may be 90% effective in blocking fertility in mares (see Wild Horse Resources, Fertility Control in Mares).
PZP has been successfully applied to control fertility in several small populations of wild horses on eastern barrier islands since the early 1990s. Population-level field trials of an injectable, time-release, pellet form of PZP that will allow almost 2 years of fertility control with a single treatment are currently underway in many western herds. The Assateague team also developed noninvasive methods to assess the pregnancy rates of, and detect ovulation in, free-ranging treated and nontreated, individually recognizable mares by analyzing reproductive steroid metabolites in their feces and urine.
PZP Field TrialsThe USGS, BLM, and USDA Animal and Plant Health Inspection Service (APHIS) have essentially completed individual-level field trials of PZP in free-roaming wild horses at three locations: Pryor Mountain Wild Horse Range, Montana and Wyoming; McCullough Peaks Herd Management Area, Wyoming; and Little Book Cliffs Wild Horse Range, Colorado. Application of PZP began in 2001 at Pryor Mountain, in 2002 at Little Book Cliffs, and in 2004 at McCullough Peaks. Results of this work in terms of horse behavior are reported in Ransom et al. (2010), and efficacy results are detailed in Ransom et al. (2011). In addition, in 2011 the USGS, BLM, and the Animal and Plant Health Inspection Service (APHIS; Department of Agriculture) began studies on the safety and efficacy of SpayVac®, a form of PZP made using a proprietary technology developed by Immunovaccine Inc. (Halifax, Nova Scotia, Canada).
Source: USGS, Fort Collins Science Center
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